姓名：胥寧

職稱：副研究員

學位：博士

郵箱：xuning@www.n3u8.com

研究方向：水產藥理學

教育經歷：

2005/09-2012/06，華中農業大學，獸醫藥理與毒理學，碩士和博士

2001/09-2005/07，青島農業大學，動物醫學，學士

主要職歷

2022/01至今，中國水產科學研究院長江水產研究所，水產信息與標準研究室，副研究員，所聘研究員

2021/01-2021/12，中國水產科學研究院長江水產研究所，水產信息與標準研究室，副研究員

2018/10-2019/10，美國堪薩斯州立大學計算藥理研究所，訪問學者

2013/03-2020/12，中國水產科學研究院長江水產研究所，水產品質量標準研究室，助理研究員

科研成果

主要論文（第一作者或通訊作者）

1.Xu, N., Li, M., Lin, Z., Ai, X. Comparative Pharmacokinetics of Sulfadiazine and Its Metabolite N4-Acetyl Sulfadiazine in Grass Carp (Ctenopharyngodon idella) at Different Temperatures after Oral Administration. Pharmaceutics, 2022, 14(4), 712.

2.Xu N, Sun W, Gong L, Liu Y, Dong J, Yang Y, Zhou S, Ai X. Comparative pharmacokinetics of doxycycline in crayfish (Procambarus clarkii) following oral, intramuscular, and intrasinus administrations. Aquaculture, 2022, 551: 737941.

3.Sun W, Chang C, Xu N ?, Wu J, Liu Y, Dong J, Zhou S, Yang Y, Yang Q, Ai X. Determination of doxycycline’s plasma protein binding rates in the plasma of grass carp (Ctenopharyngodon idella), yellow catfish (Pelteobagrus fulvidraco) and crayfish (Procambarus clarkii) by an ultrafiltration method at different temperatures with different concentrations. Aquaculture Research, 2022, 53: 2865-2873.

4.Ning Xu, Yu Fu, Xiaomei Zhang, Yongtao Liu, Yibin Yang, Shun Zhou, Jing Dong, Qiuhong Yang, Xiaohui Ai*. The pharmacokinetic characteristics of sulfadiazine in channel catfish (Ictalurus punctatus) following oral and intravenous administrations. Journal of Veterinary Pharmacology and Therapeutics, 2022, 45(1):16-22.

5.Ning Xu, Bo Cheng*, Miao Li, Zhoumeng Lin, Xiaohui Ai. Withdrawal interval estimation of doxycycline in yellow catfish (Pelteobagrus fulvidraco) using an LC-MS/MS method based upon QuEChERS sampling preparation. Foods, 2021, 10(11): 2554.

6.Ning Xu, Miao Li, Xiaohui Ai*, Zhoumeng Lin*. Determination of pharmacokinetic and pharmacokinetic-pharmacodynamic parameters of doxycycline against Edwardsiella ictaluri in yellow catfish (Pelteobagrus fulvidraco). Antibiotics, 2021, 10(3): 329.

7.Ning Xu, Yu Fu, Fang Chen, Yongtao Liu, Jing Dong, Yibin Yang, Shun Zhou, Qiuhong Yang, Xiaohui Ai. Sulfadiazine pharmacokinetics in grass carp (Ctenopharyngodon idellus) receiving oral and intravenous administrations. Journal of Veterinary Pharmacology and Therapeutics, 2021, 44(1): 86-92.

8.Ning Xu, Yu Fu, Bo Cheng, Yongtao Liu, Qiuhong Yang, Jing Dong, Yibin Yang, Shun Zhou, Yi Song and Xiaohui Ai. The pharmacokinetics of doxycycline in channel catfish (Ictalurus punctatus) following intravenous and oral administrations. Frontiers in Veterinary Science, 2020, 7: 577234.

9.Ning Xu, Miao Li, Wei-Chun Chou, Zhoumeng Lin. A physiological based pharmacokinetic model of doxycycline for predicting tissue residues and withdrawal intervals in grass carp (Ctenopharyngodon idella). Food and Chemical Toxicology, 2020, 137,111127.

10.Ning Xu, Miao Li, Yu Fu, Xiaomei Zhang, Xiaohui Ai, Zhoumeng Lin. Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon Idella, following multiple oral administration. Food and Chemical Toxicology, 2019, 131: 110592.

11.Ning Xu, Miao Li, Yu Fu, Xiaomei Zhang, Jing Dong, Yongtao Liu, Shun Zhou, Xiaohui Ai, Zhoumeng Lin. Effect of temperature on plasma and tissue kinetics of doxycycline in grass carp (ctenopharyngodon idella) after oral administration. Aquaculture, 2019, 511: 734204.

12.Ning Xu, Jing Dong, Yibin Yang, Yongtao Liu, Qiuhong Yang, Xiaohui Ai. Development of a liquid chromatography–tandem mass spectrometry method with modi?ed QuEChERS extraction for the quanti?cation of mebendazole and its metabolites, albendazole and its metabolites, and levamisole in edible tissues of aquatic animals. Food Chemistry, 2018,269:442-449 (IF=9.2).

13.Ning Xu, Jing Dong, Zhou Wei, Yongtao Liu, Xiaohui Ai. Determination of Doxycycline, 4-epidoxycycline, and 6-epidoxycycline in Aquatic Animal Muscle Tissue by an Optimized Extraction Protocol and Ultra-performance Performance Liquid Chromatography with Ultraviolet Detection. Analytical Letters, 2018, 52(3): 452-464.

14.Ning Xu, Jing Dong, Yibin Yang, Xiaohui Ai. Pharmacokinetics and depletion of praziquantel in rice field eel (Monopterus albus). Diseases of Aquatic Organisms. 2016, 119: 67-74.

15.Ning Xu, Jing Dong, Yibin Yang, Qiuhong Yang, Yongtao Liu, Xiaohui Ai. Pharmacokinetics and bioavailability of flumequine in blunt snout bream (Megalobrama amblycephala) after intravascular and oral administrations. Journal of Veterinary Pharmacology and Therapeutics. 2016, 39(2):191-195.

16.Ning Xu, Binbin Gong, Jing Dong, Yibin Yang and Xiaohui Ai. Single intravascular and oral dose pharmacokinetics of mebendazole in blunt snout bream, Megalobrama amblycephala. Journal of the World Aquaculture Society, 2016, 47(5):685-690.

17.Ning Xu, Xiaohui Ai, Yongtao Liu, Qiuhong Yang. Comparative pharmacokinetics of norfloxacin nicotinate in common carp (Cyprinus carpio) and crucian carp (Carassius auratus) after oral adminiatration. Journal of Veterinary Pharmacology and Therapeutics. 2015, 38 (3):309-312

18.Huang Lingli1, Xu Ning, Sechenchogt Harnud1, Pan Yuanhu, Chen Dongmei, Tao Yanfei, Liu Zhenli, and Yuan Zonghui. Metabolic Disposition and Elimination of Cyadox in Pigs, Chickens, Carp, and Rats. Journal of Agricultural and Food Chemistry, 2015, 63 (22), 5557–5569.

19.Ning Xu, Lingli Huang, Zhenli Liu, Yanhu Pan, Xu Wang, Yanfei Tao, Dongmei Chen, Yulian Wang, Dapeng Peng, Zonghui Yuan﹡. Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Communication in Mass Spectrometry. 25 (16): 2333-2344, 2011.

20.胥寧，鄭全輝，劉永濤，周順，楊移斌，董靖，楊秋紅，艾曉輝.甲苯咪唑在團頭魴體內的物料平衡.華中農業大學學報，2022, 41(2): 185-190.

21.胥寧，楊移斌，劉永濤，董靖，楊秋紅，艾曉輝. 混飼對吡喹酮在草魚體內藥動學和生物利用度的影響. 淡水漁業，2018, 5: 73-78

22.胥寧，劉永濤，楊秋紅，艾曉輝. 喹烯酮在草魚體內生理藥動模型的建立.水生生物學報，2015，39（3）：517-523．

23.胥寧，劉永濤，艾曉輝，趙鳳，楊秋紅，呂思陽. 甲苯咪唑在團頭魴體內主要代謝物及其變化規律研究.淡水漁業，43（6）：42-46，2013.

授權發明和實用新型專利

1.胥寧，艾曉輝，董靖，劉永濤，楊移斌，楊秋紅. 水產品中苯并咪唑及噻唑類殘留藥物的快速提取及LC-MS-MS檢測方法. ZL 201710222141.1

2.胥寧，艾曉輝，董靖，周偉，劉永濤，諶芳. 水產品中多西環素及代謝產物的快速提取及檢測方法. ZL 201810390452.3

3.胥寧，艾曉輝，楊秋紅，劉永濤，董靖，楊移斌. 一種生理藥動學模型預測草魚組織中藥物殘留的方法. ZL201410537997.4

4.胥寧，艾曉輝，董靖，劉永濤，張曉梅，付鈺.一種魚類背主動脈插管.ZL 201820629267.0.

5.胥寧，艾曉輝，董靖，楊移斌，劉永濤，楊秋紅. 一種適于魚類生理參數測定的實驗裝置.ZL 201720042733.0

獲獎成果

1.稻田小龍蝦綠色高效養殖和質量安全控制關鍵技術與應用，湖北省科技進步二等獎，2021年，第七完成人

2.典型養殖魚類藥物代謝殘留規律及模型預測技術研究，中國水產科學研究院科學技術獎二等獎，2021年，第5完成人

3.斑點叉尾鮰安全生產關鍵技術, 湖北省科技進步二等獎, 2014年, 第10完成人

4.斑點叉尾鮰安全生產關鍵技術, 中國水產科學研究院科技進步二等獎, 2013年, 第10完成人

主持和參與主要項目

1.國家自然科學基金面上項目，基于生理藥動學可視化界面對恩諾沙星及代謝物在魚體休藥期預測及外推，32173022，主持；

2.湖北省自然科學基金面上項目，基于生理藥動學模型對多西環素在草魚體內的殘留預測，2019CFB636，主持；

3.國家留學基金委公派出國項目，漁藥在魚體內生理藥動學模型的建立，201803260013，主持；

4.中國水產科學研究院基本科研業務費，基于PK/PD模型多西環素對鮰愛德華氏菌的防耐藥突變研究，2017HY-ZC03，主持；

5.中國水產科學研究院基本科研業務費，吡喹酮在草魚體內代謝，2015JBFM29，主持；

6.國家重點研發計劃，水產品全鏈條關鍵危害物的遷移轉化規律與安全防控技術研究子課題“典型養殖用藥的遷移規律及防控技術”，2017YFC1600704，參與；

7.湖北省重大項目，蝦-稻高效養殖與質量安全控制關鍵技術研究，2019ABA077，參與；

8.國家現代農業產業技術體系，特色淡水魚產業技術體系質量安全崗位專家分解任務，參與。